Rebirth of the God-level Xueba

Chapter 140 Summary

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After Yao Yue started working, she was still a little uneasy.

But soon, she realized that she didn’t need to be worried.

Because Yang Rui is so serious about her work, she has no time to care about whether her dress and white coat are really company.

The workload of producing Coenzyme Q10 by plant extraction method is too great.

In particular, Yang Rui is ambitious and wants to build a research and development chain. This task is even heavier.

In order to finally produce cheaper coenzyme Q10, the most important step is to extract the intermediate product solanesol from tobacco leaves, and then use solanesol as the intermediate product to chemically synthesize coenzyme Q10.

The extraction of solanesol from tobacco leaves actually has related technologies.

Even using solanesol as a raw material to chemically synthesize coenzyme Q10, there were related papers and laboratory results in 59 years.

However, the thesis is the thesis after all, and the research is the research after all. It is like pure chemical synthesis of coenzyme Q10. Since the 1960s, there have been related papers and researches. More than one team has obtained coenzyme Q10 through chemical synthesis. However, until half a century later, the production of coenzyme Q10 by chemical synthesis still cannot be industrialized.

The semi-plant extraction and semi-chemical synthesis method took about 30 years to mature. The key factor is to use 90% pure solanesol as the raw material.

Now that he is aware of this, Yang Rui may be the only person in the world.

It can be said that just such a sentence can be exchanged for an industry worth billions of dollars in the future.

It’s a pity that Yang Rui can’t just say that.

If he speaks out an experiment or a paper, he may be highly praised and affirmed by the biological world, but he doesn’t need to think about money.

Japan, West Germany, the United States, France, the United Kingdom…There are too many super-pharmaceutical companies that can use a strong research team and a team of pure gold lawyers to throw Yang Rui out of the income zone.

It is somewhat arbitrary to say that large pharmaceutical companies are the most despicable companies in the world, but whoever wants to say that they are not despicable will definitely get the bad luck.

Even the employees of pharmaceutical companies can only say that our company is charitable at best, but they can’t say that their company is charitable.

Therefore, Yang Rui must build a series of key technologies around the core technology, and then use a series of technologies to surround a series of key technologies.

For example, the synthesis of 90% pure solanesol requires a series of key technical support.

The advantage of this layer of barriers is that Yang Rui does not need to apply for patents on core technologies, or simply make patented submarines, and use strict confidentiality to produce only finished products for sale.

This is also a magic weapon for small and medium-sized biotech companies to survive.

In the early 1980s, many biotech companies still didn’t understand this, thinking that patents could protect themselves, and they were scammed by large pharmaceutical companies one by one.

In this year, the average lifespan of biotech companies in the United States was only 36 months. If a legal fee is added, most of the medium-sized biotech companies with a capital of less than US$50 million will not survive for 18 months at all.

At the level of large pharmaceutical companies, let alone delays for 18 months, lawsuits involving delays of more than 8 years abound.

This is also one of the reasons why Yang Rui dare not make medicines for the time being.

Western medicine has a fixed name, usually a compound. Moreover, most of them are derivatives of compounds known in the medical field, except that the side chains are different, which is not surprising.

For this kind of medicine, it is very simple to be copied. If it is to make money, it is almost natural to be copied.

The production technology is quite different. As long as the secrecy is done well, coupled with certain technological upgrades, it is no problem to maintain monopoly benefits for several years.

Biotechnology companies have monopolized the money earned for several years, no matter how small the field, it means a huge amount of money.

Japanese pharmaceutical companies use semi-plant and semi-chemical synthesis, which is five or six years, and the accumulated funds are enough to complete the research and development of the microbial fermentation method, and at the same time, the dividends are soft.

Yang Rui has now developed the technology of plant extraction and semi-chemical synthesis, and he can make a few more years.

Thinking of this, Yang Rui is also very motivated.

In just one weekend, several verification experiments were completed.

He didn’t mean to stop, and continued to find a few journals and continue to do verification experiments. At the same time, Yang Rui also began to write the first review.

In academia, review can be regarded as a high-level popular science.

A review is a paper in which the author summarizes the data, information and opinions of a large number of papers for a certain topic, and then analyzes and refines the paper.

To put it simply, Yang Rui only needs to summarize the article he has read recently around a proposition, and it is even a review.

For example, “The Research Status of Solanesol” is an ordinary review article.

However, it is more difficult for such articles to be published, and it is even more difficult for them to be published in better journals.

In European and American countries, especially the United States and the United Kingdom, it is often the experts in the field who write reviews, and they have the feeling of giving lectures to ordinary researchers in simple terms.

Of course, their motivation for writing reviews is usually not so pure. Most of the time, Daniel writes a review in order to mix up the index of the paper. Because many foreign schools also have hard requirements for how many papers to write every year or every few years, some big cows are either lazy, or because of excellence, and can’t complete the required number, so they write a review and get confused.

Because it is an advanced science, you don’t need to do in-depth research. After checking some information, you can usually write a summary in a few days.

Domestic reviews are often written by gentlemen who are far away from Daniel. Some graduate students who can’t produce a thesis or want to mix one, some young lecturers who can’t complete their tasks, or busy associate professors are all big reviewers. The level is naturally uneven, so that some departments simply The overview is listed separately.

However, the Chinese academic circles in the 1980s were not so particular, limited by their level, review is still a very popular category, and people who rely on its mixed titles are like the crucian carp.

Yang Rui didn’t want to waste his own research on so much information. In addition, the more technical barriers the paper is, the better, and he started writing unceremoniously.

Lü Zhi, who helped in the laboratory, saw his writing relaxed, and wrote a large page in one afternoon. He couldn’t help asking, “That’s how you wrote a paper?”

“This is the first one, starting from a simple one.” Yang Rui didn’t write the paper slowly, because a lot of information is in his mind, and he has a clear understanding of the future development direction, so it is naturally easier to write a summary.

Seeing that what he wrote was all in English, Lv Zhi naturally knew that he was going to publish it abroad, so he couldn’t help asking: “Can you really publish it?”

Yang Rui said irritably, “I can’t publish it. What shall I write.”

“It’s normal to write an article and not publish it. Many brothers and sisters are trying hard to make changes, some of them have to be changed for several years.” Lu Zhi is still struggling. If he is not struggling enough, he can’t remember to publish an article abroad. .

Yang Rui smiled disapprovingly: “I am different from them.”

Now, even Yao Yue asked: “Where is it different?”

“Talent.” Yang Rui pointed to his head and said half-truth: “I have a lot of things in my head.”

“You want to say that my head is empty.” Lu Zhi is not proficient in doing experiments. She has not had many opportunities to get in touch with the instrument, let alone Yang Rui’s unfamiliar instrument here. In the past two days, her performance has not been as good as that of a middle school student. Some emotions have accumulated.

A stupid girl like Lu Zhi poured out an idea right away and couldn’t keep it.

Yang Rui laughed twice, and silently acquiesced.

Lu Zhi was anxious, and pulled Yao Yue: “Let’s leave. We won’t do it for him. Not only is it tired, but also scolded. It’s a capitalist. Who does it for you, who is a puppy.”

Yao Yue was embarrassed, Yang Rui said quietly: “Thank you for making braised pork at noon in the cafeteria.”

Lu Zhi stopped unconsciously, and after a while, he whispered softly: “Wang!”

Yao Yue couldn’t laugh or cry, so as to say in shame: “Lu Zhi, you can’t just…”

“Just what?”

“Just called…” Yao Yue stomped her foot before speaking completely.

Lu Zhi said indifferently: “What is this? When the educated youth order, if the kitchen makes a pot of braised pork, everyone can queue up for a day. If the order is over and there is no braised pork, everyone can rush to kill the captain in the kitchen. .”

The last sentence is obviously a threat to Yang Rui.

“Have you ever been an educated youth?” Yang Rui quickly changed the subject.

“There are a lot of educated youths in school. I went home and re-entered for a year before getting admitted. Fortunately, I got admitted, otherwise I would have to go to the coal mine. A former classmate of mine went to the coal mine for two years of beneficiation, but his tinnitus I couldn’t fall asleep at night, I said it was the sound of a brain full of machines.” Lu Zhi complained mixedly with gratefulness.

He Cheng, who has been doing experiments all the time, heard this and suddenly said: “My second cousin sold the pigs at home and bought cigarettes and alcohol as gifts in order to enter the coal mine last year. , I got regular. Their family eats vegetarian dumplings during the Spring Festival.”

Going in a coal mine is not as good as studying, but it is better to be a farmer than to go to the coal mine. This answer immediately silenced the two college girls.

Yang Rui didn’t like this atmosphere. He coughed and said, “Yao Yue, you also write a review and show it to me next week.”

“Me? I still don’t understand some words…” Yao Yue was a little nervous. Now there is no search engine that can help translate English. Every word that you don’t know has to be found out one by one. Uncommon professional English can only be found out in professional dictionaries. The workload is huge Yang Rui shook his head: “Not let If you write in English, you should first write an article in Chinese. Anyway, it’s not a waste. It’s a bit of experience. I’ll fix the paper for you and then teach you how to write a submission letter. The signature will be your own.”

Just like a big cow in later generations, Yang Rui didn’t bother to leave his name in ordinary domestic journals, not to mention this kind of summary articles like writing practice.

Yao Yue relaxed for a while, then nervous again, and whispered, “Can I write it out?”

“How do you know if you don’t try it. Okay, you can go and pack your bags and go back after lunch. Yao Yue, you have questions and mail…mail me, write a letter, um, I have experiments for you, too I will write to you explaining the experimental requirements and steps, and you will post the detailed content back when you have the results. Remember to memorize the English words and start reading the English literature next month.” In addition to being mailed, Yang Rui’s request and his second study , The requirements of the instructor are almost the same.

There are so few graduate students this year. Excellent undergraduates originally had to undertake the task of assisting in the experiment. Yang Rui now has an understanding of Yao Yue’s experimental ability. As long as she does not assign tasks that exceed her ability, there will not be too many omissions.

Lu Zhi silently read about the braised pork, and briskly went to the dressing room. Yao Yue left a little hesitantly. He had nostalgia for the laboratory and people as well as the expectation of writing a paper by himself.

“If the classmates knew that I had the opportunity to write and publish independently, they would be envious.” Yao Yue’s vanity also fermented slightly. She is a sophomore girl this year. If she has the opportunity to publish a paper, she might be the man of the year in Hedong University.

…