Rebirth of the God-level Xueba

Chapter 1567



Chapter 1499 Dial the phone

“Professor.” Huang Mao knocked gently on the door and entered Yang Rui’s office.

“Oh, Huang Mao, something?” Yang Rui rubbed his temples, still immersed in the fatigue of continuous telephone communication.

Changing the test items of a new drug is not a simple matter. Many new drugs will try to add new indications after they are on sale. However, if a new drug has not passed the clinical trials, it would like to change its indications, which is tantamount to failing.

The FDA will only be more demanding on new drugs that have failed re-examination.

More often, it is not approved.

Historically, Pfizer also took a lot of effort to replace the indications for sildenafil. It took more than half a year and an unexplainable price to let the FDA relax.

Compared with Pfizer, the largest pharmaceutical company in the United States, Greenstone Point, which cooperates with Huarui, is just a little guy. Its scale is less than one-tenth of Pfizer’s. The government relationship is even weaker as a dog. Long-term cooperation is said. The customer company has less than 30 members of Congress that can influence it, and it lacks **** supporters, and its public relations funds and industry power are not outstanding.

Yang Rui can only take side measures to influence the FDA.

To this end, Yang Rui published a “science”.

Indeed, it is very difficult to publish the “Science” of the world’s three major journals. Scholars in any country at any time, if they want to publish an article to “Science”, if it is not for luck, they can only hold back their big moves.

One scholar assumed that he started experimenting at the age of 40 to collect data and suffocated his big move. When he was 50 years old, the collected data would be eligible to contribute to Science. Whether it can be published or not is still two different things.

“Science” is aimed at all fields, but everything in the field of science, from traditional physical chemistry, popular computer hardware and software, excavation of uncommon palaeontology, and research on Egyptian characters, is qualified. It is the most extensively involved in the CNS. It can be said that except for the pure liberal arts projects involved in the liberal arts monks, anyone has the hope of publishing “Science”.

From the perspective of the paper, the number of submissions per year is also an astronomical number.

Fortunately, there are only a hundred articles published every year. The probability is so low and too low that most scholars regard it as good luck.

Yang Rui is the only one who wants to hold down the G point of “Science”.

The title of Nobel Prize winner is only one aspect-but it has to be said that its effect is very large, especially for young and active Nobel Prize winners, the moment its articles fall into the hands of the editor From the beginning, it is bound to receive extreme attention.

The particularity of sildenafil, especially the prevalence of nitric oxide-related topics, has brought more recognition.

If there are no additional changes, by 1992, nitric oxide will be named the molecule of the year by Science.

In recent years, the topic of nitric oxide has become too hot.

Any relevant research will be highly regarded in any journal.

Not to mention the nitric oxide compounds brought by the Nobel Prize winners.

Sildenafil can make the cavernous body harden because it stimulates the body and releases nitric oxide.

From this perspective, eating Viagra is to inflate yourself.

What “Science” wants to publish is the inflation process.

Pfizer may be very good in the business field, but they have not been able to do it and there is no need to make “Science” follow its orders.

Sildenafil was previously only a useful compound that was screened by a commercial company. Although it was sold for US$180 million, it may not be regarded as “seen by Yang Rui” in the eyes of the scientific community.

The chemists responsible for clinical experiments on sildenafil are only the fourth-rate scientists in the world-the first-rate Nobel Prize, the second-rate Nobel Prize, the third-rate lectures at prestigious universities, the fourth-rate tenured professors-the fourth-rate scientists. Although it is also world-class in the eyes, “Science” has never been in the eyes of the public.

However, when Comrade Yang Rui, the world’s first-order scientist, analyzed the whole sildenafil and described it completely from the viewpoint of nitric oxide theory, “Science” also had to give way.

For a superben like Yang Rui, he just published a review of nitric oxide, which will be published in Science, not to mention a paper with complete data and novel ideas.

The most important thing about the paper is actually the idea.

When it comes to graduate school, how do you distinguish between good students and students? Is it to see who kills the mouse and kills the wonderful thing? It’s nothing more than whose ideas are brilliant and who is powerful.

The same goes for scholars, professors, and scientists. There are scientific research dogs doing the work. The workload is nothing more than using a few more scientific research dogs, spending a few more than 1,200 each month. The classification of classes depends on the thinking in the end.

And when Yang Rui needs to put forward subtle ideas, it is not that he is not humble, everyone else is scum.

“Science” magazine was also instantly second.

Several reviewers contacted the editor at the first time, gave an evaluation of the passage of the article, and strongly recommended the double-anonymity system for scientific research papers, which is useless among high-end scholars.

Not to mention whether the journals themselves can firmly abide by Nobel scholars, but the resources of high-end scholars are sufficient to break through this barrier.

As long as the word “sildenafil” appears in the paper, everyone can think of Yang Rui as soon as possible.

The news that he spent 180 million to buy Pfizer did not hide it. Anyone who cares about the scientific community can more or less hear the news, especially in related circles. Besides, the review is not a closed-book examination, and the reviewer also needs reference materials. No matter what position is used to read it, it is impossible to miss Yang Rui’s news.

The news of “Yang Rui has made new results” was spread before the latest issue of “Science” was published, and “Science” had to be scheduled as quickly as possible.

Yang Rui didn’t need to actively promote the whole process, and he completed it easily.

When the people at Greenstone Point took “Science” to the FDA, in fact, FDA scientists also received the news.

To say that the FDA, for pharmaceutical companies, is indeed a god-like existence, and it cannot be overstated. Especially after the 1980s, the authority of the FDA can be said to be extremely powerful.

However, the FDA is not invincible.

Its fate is science.

The independence and authority of the FDA is based on science, and most of the scientists who serve it are some well-known experts in the industry.

These people can make decisions based on their own opinions, just as Yang Rui had made to Lu Bo that day, but when faced with scientific problems, their independence had to be shaken.

The scientific issues raised by ordinary scholars certainly cannot shake the FDA’s experts.

However, if they are indifferent to the demands of Nobel Prize winner Yang Rui, a scholar who is in the active period of scientific research, then their reputation and independence will be greatly compromised.

Bureaucrats and procrastination are not allowed to respond to the documents submitted by Yang Rui.

The only reason they can reject Yang Rui is science itself.

This is also the reason why pharmaceutical companies have hired Nobel Prize winners after the 1990s. However, the reality is that few pharmaceutical companies can actually hire Nobel Prize winners who are active in scientific research.

The Nobel Prize in Medicine and Physiology is given to three people at most each year, and many of them are given to old men.

Young and middle-aged scholars have a low chance of receiving the Nobel Prize. Those who are willing to give up scientific research and go to pharmaceutical companies are really rare.

It is Yang Rui. Sildenafil is also a part-time job. If it weren’t for Viagra’s amazing profits, he could save time and make money to increase scientific research funds, change a medicine, and Yang Rui, who won the Nobel Prize, would not be so dedicated. Do your best.

For the world’s first-order scientists, time is the most important resource, and money is not important anymore.

Rather than discussing the importance of money, it is better to discuss social wealth. Anyway, their money is calculated according to the proportion of GDP.

Sildenafil’s request to change its indications passed the FDA’s approval faster than in history-“Science” has been published. It still takes courage to go against the mainstream scientific community.

This time, the FDA did not show it.

For Yang Rui, the whole thing was very strenuous, and for Huang Mao, who presided over the clinical experiment, it was stressful.

“Professor, this is the list of volunteers for the second clinical phase.” Huang Mao lowered his head and put a thick notebook on the table, making a sound.

Yang Rui glanced at it, and his eyebrows frowned: “You made a mistake.”

No, the hard-skinned, thread-bound notebooks are all used to write names…

“There are a total of 27,427 people.” Huang Mao said: “Volunteers who are obviously inappropriate have been eliminated.”

“27427 people, it’s a lot…” Yang Rui guessed that many people would come to sign up, but he didn’t expect that there would be so many people.

“It’s more.” Huang Mao couldn’t help but vomit: “I checked the literature. Generally, hundreds of people sign up for clinical trials like foreign countries, and most of them are recommended by doctors.”

The recommendation of a practicing physician is very important for the clinical trials of pharmaceutical companies, especially the second phase of trials. The safety issue has not been completely resolved. There is no trusted doctor to tell you that this is the most appropriate choice. The projects are all in a minority, let alone sign up.

“Do they know the meaning of Phase II?” Yang Rui couldn’t help but said: “We just made a mistake before. Do they know the danger?”

“I guess I know it.” Huang Mao paused and said, “The problem is not how many of them are I can select them if there are too many people. You can see the identities of these people.”

Huang Mao opened the thread-bound hardcover to a place with a bend, and he saw a string of conspicuous work units and names behind a person’s name.

The name of a whole page is the same.

“Good guy, you don’t need to wait in line if you fly by plane.” Yang Rui sighed.

Huang Mao rolled his eyes and couldn’t say that Yang Rui was wrong.

“What should I do now?” Huang Mao asked: “Some people have called. I picked up two of them and hurriedly pulled out the phone. Didn’t you receive the call?”

Yang Rui was taken aback for a moment and said, “I have not been in the clinical trial center for these two days.”

Jingle Bell.

While talking, the phone that I just hung up rang again.

Yang Rui hesitated for a moment, and then picked it up. He said twice, “I understand what Mr. Li said. In this way, I will ask Huang Mao to see what arrangements he has made.”

After speaking, Yang Rui hung up the phone and unplugged the phone line decisively.

Huang Mao stared at Yang Rui with piercing little eyes.

Yang Rui shrugged, pointed to the thick book, and said, “This comparable book is a big name.”

“Then…what should I do?” Huang Mao was helpless: “It really doesn’t work, let’s make arrangements?”

“Just kidding, if something goes wrong, you are a rare massacre in the world.” Yang Rui vetoed it. The so-called life is a matter of life, although he knows that sildenafil is okay, what loopholes are there in the maintenance of unevenness?

As a scholar, it would be a joke even if it succeeded in the second phase of clinical practice to reach tens of thousands of people.

“If this doesn’t work, let’s apply for the provincial medicine quasi-character simultaneously.” Huang Mao had already thought about it before he came to Yang Rui.

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