Great Power Technology.

Chapter 624 Phase Zero Experiment Results

On the other hand, after clearing all obstacles, the zero-stage research and development of immune reconstruction therapy has finally come to an end.
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Yes, not the beginning, but the end.

In fact, after receiving the technical documentation provided by Ye Zhou, a research team composed of top domestic clinical experts has been dispatched, and their task is also very simple, that is, to follow the technical manual 100% The first case of immune reconstitution therapy was reproduced in China.

Now that they have completed all the mouse experiments, they are discussing the actual efficacy and human safety results before the latest output report.

"Has a preclinical model of B-NDG mice come out? What are the results?"

The person who asked the question was a white-haired old man sitting in the middle named Xuan Cheng. He is a veteran in the field of immune reconstruction therapy in China and has made great contributions to PBMC therapy.

"It has basically come out. Judging from the current results, the survival rate of this batch of mice has reached 100%, but there are fluctuations in the survival cycle. In a period of time after receiving the experiment, more than 20% of the mice appeared significant weight loss."

"At the same time, we also observed a small number of experimental subjects showing mania, anxiety, and even self-biting."

"Controlled trials have been done many times, including adjustments in PBMC dosage and therapy, but strangely, this problem persists."

The person who answered was Lin Qingshu, the leader of the zero-stage working group. His face was full of doubts, as if he was completely puzzled by the result.

In fact, from his point of view, this question is indeed as evil as hitting a ghost.

All the variables that can be adjusted and controlled have been adjusted, and all man-made or non-man-made disturbances have been ruled out. They even changed the experimental cabin several times, but the diseased mice still developed the disease.
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In other words, it cannot be called a disease, because the mice did not show obvious morbid traits, and the signs were all normal. If the requirements of other non-core experiments were followed, this could even be regarded as a non-critical factor and skipped.

After all, there are many reasons for rats to go crazy. It may be because of temperature changes, it may be because the air is too dry, or it may even be because they accidentally stepped on a static electricity...

However, in such a project, he couldn't ignore any slight anomaly, because at this stage they were not exploring, but just replicating.

The first basic theorem he can determine is: instead of questioning whether the technical documentation will be wrong, it is better to re-examine the execution process.

Therefore, based on this judgment, they even changed the fresh air system in the laboratory, but it still did not solve the problem that the treated mice went crazy every now and then.

"Could it be a GVHD problem caused by a high proportion of human immune cells?"

Xuan Cheng frowned and asked.

The so-called GVHD is commonly known as graft-versus-host disease, which may appear in any immune reconstruction therapy involving PBMC.

"No, we have tried to adjust many times, and we have ruled out most of the variables, and we are sure that it is not caused by GVHD."

"What about the operating process? Are there any non-standard actions caused by human factors?"

"No, we're just short of replaying the video frame by frame."

Lin Qingshu sighed and spread his hands helplessly.

Hearing this, everyone in the conference room fell silent. They all knew how important the phase zero experiment of this project was.

Not only because the laboratory results will be urgently applied to a group of patients with severe immune diseases to save their few remaining lives.

More importantly, the results this time will verify an important question:
That is, whether the immune reconstruction technology has broken through the upper limit of the current human technology level in the whole process.

If there is no way to reproduce it in the laboratory, there is no need to talk about large-scale rollout.

The entire follow-up project strategy will be affected. The originally planned "results"-oriented strategy will gradually be transformed into a "construction"-oriented strategy, and the resource input plan will also need to be changed.

"Could it be an allergic reaction?"

After a few seconds of silence, Xuan Cheng continued to ask.

"Allergic reaction?"

Lin Qingshu was stunned for a moment, unable to realize what the other party meant.

Allergic reactions in the experiment are actually not a particularly rare thing, but the problem is that if there is an allergy, it means that there is a problem with the equipment or medicine used. All the mice in the same batch should be allergic. How come there are only a few of them? Only problem?
But then again, the behavior of mice is indeed a bit like allergies now.

He frowned and thought for a moment, then replied:
"We don't seem to have checked IGE... Well, I'll ask the laboratory to check IGE first. If the value continues to be high, then consider an allergic reaction."

"But the problem is, we've never had this kind of situation before..."

"Don't worry about whether it has appeared or not."

Xuan Cheng interrupted him and continued:
"Now that you've done a thorough experiment and ruled out all other variables, allergies are the most likely cause of the problem."

"You don't have to have too little confidence in yourself. This technology is indeed advanced, but it is not beyond your own capabilities."

"There is no need to suspect that something is wrong with me if there is a little abnormal result--check IGE first!"

"understand!"

Lin Qingshu went out with the report, while Xuancheng stayed where he was and looked at the overall experimental results.

As Lin Qingshu reported before, judging from the final data results, the results of the entire zero-stage experiment are very good. If it is not for the intermittent mania in mice, they can even directly end the problem and start applying for human experiments.

The time for the whole project is very tight, and if it is delayed now, it will affect the entire cycle.

what is the reason behind the scene?

Lin Qingshu is quite right. Allergic reactions should not only appear in some mice, because the variables are the same. It is impossible for one group of mice to be allergic to a certain allergen while the other group is not allergic, right?
The probability of this is there, but it is too low.

He was immersed in his own thoughts, and the time passed quickly. In less than half an hour, the door of the meeting room was pushed open again.

"Teacher Xuan, the IGE is really elevated, it seems to be an allergy!"

Xuan Cheng was refreshed, and continued to ask:

"Can you locate the allergen?"

"Currently we can't locate them, but we can test them one by one...it shouldn't take much time."

"Also, I have a hunch that the problem this time is likely to be on the device!"

"Equipment? What equipment?"

Xuan Cheng asked suspiciously.

"Needle! Or if it's not a needle, it's a SUT!"

(End of this chapter)