I Just Want to Be a Quiet Top Student

Chapter 536 New plan and new results

The molecular skeleton of oxygen-containing hybrid ring compounds is widely present in many natural products with important biological activities and artificially synthesized drug molecules.

In order to obtain a high-yield target molecule, Shen Qi and others designed a new synthetic route, but the yield of c01c-2 is still very low.

“You two have worked hard.” Sitting in front of the computer, Shen Qi seemed to have a new idea.

“Our level is limited and I disappointed Director Shen.” Lao Yan said sorry that he and Cheng Haonan were both masters of chemistry. Maybe it was because the educational background was too low, and the tasks that Director Shen confessed could not be completed well.

“Lao Yan, do me a favor, go to the academy, and give this to Ou Ye.” Shen Qi handed Lao Yan a file bag containing mathematical data.

“Okay.” Old Yan took the file bag, feeling a sense of crisis in his heart. If the scientific research task is not completed well, he will be downgraded to a handyman.

Shen Qi took out a few coupons to Cheng Haonan: “Old Cheng, I cross the street when I am out of the east gate of the school. There is a newly opened restaurant. The dishes are well done. These are vouchers. You can pack a few dishes and come back. There will be three at noon.”

“ok.” Cheng Haonan also has a sense of crisis, and he is reduced to a takeaway.

Lao Yan and Cheng Haonan walked hard and left the center. They followed Shen Qi’s instructions to do their own things.

Compared to developing a new organic reaction, sending a copy of information to Mrs. Shen and buying a takeaway, this kind of business is not difficult. The two quickly completed the task and returned to the center.

The whiteboard is full of chemical formulas and reaction steps, which seems to be written by Shen Qigang.

“this is……”

“Is this…”

Lao Yan and Cheng Haonan were all shocked. After only half an hour, Director Shen worked out a new plan?

“Come, eat, and talk while eating.” Shen Qi pointed to the takeaway box that Cheng Haonan was carrying.

The three of them ate fish and nibbled meat, and discussed the optimization plan of c01c-2.

It was mainly Shen Qi who was talking, and the other two listened respectfully.

“Based on the results of your work, I conducted an analysis. Using o-methoxybenzyl alcohol instead of o-carboxybenzyl alcohol and o-carboxystyrene, even if the reaction is carried out under optimal conditions, it is difficult to proceed. Using methyl-protected benzene Ethylene instead of o-carboxystyrene and o-carboxybenzyl alcohol does not work either.”

“So I speculate that the possible activation mode of the reaction is that the chiral phosphoric acid simultaneously forms hydrogen bonds with the o-carboxybenzyl alcohol in-situ intermediate and o-carboxystyrene, which promotes the occurrence of the 42 cycloaddition reaction, thereby increasing the c01c- 2. The total yield of 2. Reasonably deduced from the perspective of the reaction mechanism, the electronic effect of the substituent has a certain influence on the enantioselectivity of the reaction. Of course, this is my guess, and everything is subject to experimental data.” Shen Qi Using the time of lunch, he explained his idea.

After lunch, Lao Yan and Cheng Haonan came to the chemistry laboratory to verify Shen Qi’s speculation.

The mood of the two is complicated. If Shen Qi’s speculation is correct, then a new and valuable organic reaction will be born in the Yan University laboratory. This is exciting and good news.

also shows that the academic level of Lao Yan and Cheng Haonan is far from that of Shen Qi.

The two of them worked hard for a few months and couldn’t get satisfactory results, but Shen Qi finished it with one meal.

Shen Qi must take the initiative to solve academic problems. Lao Yan and Cheng Haonan pessimistically believe that the necessity of their own existence is not high.

“Lao Yan, you said, Director Shen is so amazing?”

“I have to admit that Director Shen’s theoretical skills are extremely profound and can be described as unfathomable. Once he shows up, he will be incomprehensible, but very powerful.”

“Your sister, the addition is wrong!”

Cheng Haonan roared and hurriedly stopped the experiment.

The two were patronizing and talking. Old Yan mistakenly added dichloroethane as a catalyst to the reaction vessel, and the mistake in the chemical addition step caused the laboratory to be filled with smoke.

“Wandering, **** it!” Lao Yan dealt with the experimental error in a low-key manner, and did not report to the center leader. He increased the ventilation and restored the laboratory to normal state.

The two never dared to chat about Director Shen’s gossip, they just focused on experimenting.

This experiment lasted for two days and two nights. A new day came and the morning sun rose.

The target product was successfully synthesized. It was c01c-2. It was synthesized by Lao Yan and Cheng Haonan nearly a hundred times in a few months, but none of them qualified.

Will it repeat the same mistakes this time?

After completing the nuclear magnetic hydrogen spectrum, carbon spectrum, infrared spectrum and other tests, Lao Yan showed a dementia-like expression: “The total yield is 55%…”

Cheng Haonan murmured: “The ee value is 70%…Shen Qi, the gods are also.”

The experimental data is perfect. This data means that the new reaction conceived by Shen Qi is reasonable. The addition of this reaction will cause the total yield of c01c-2 to soar from less than 1% to 55%.

And c01c-2 is an enhanced version of c01c, which theoretically has safer drug properties.

Of course, the safety of c01c-2 still needs to be confirmed by animal experiments and clinical trials.

As a chemist, for Lao Yan and Cheng Haonan, an improvement of an experimental procedure resulted in a target compound with a yield of more than 50 times. This is a magical operation.

And this **** operation they can’t achieve it.

“Director Shen’s operation is really incomprehensible, but I have to admire it.” Old Yan saves the experimental data, no matter what, this new reaction, the two of them participated in the experimental process.

Cheng Haonan comforted Lao Yan: “Brother, our positioning needs to be adjusted. In fact, you are skilled operators just like me. The most high-end route design and reaction mechanism research are done by chemists and by Director Shen. Things. What we have to do is to implement Director Shen’s synthesis strategy and complete specific synthesis experiments. To put it bluntly, we are just two experimental dogs with strong hands-on ability. If you figure this out, you may not be so sad.”

“Your remarks are too truthful and have caused me intense discomfort.” Lao Yan completely thought about it, why he had a sense of crisis before, why was he sad because of the unpretty data, and even doubted his academic level?

Because Lao Yan has been with Shen Qi for a long time, he takes Shen Qi as an example. He wants to do what Shen Qi can do.

However, it turns out that what Shen Qi can easily do, Lao Yan and Cheng Haonan can’t do even if they want to break their minds.

“Everyone’s brain structure is different. Let’s go and report the results to the leaders.” Cheng Haonan and Lao Yan came to the director’s office with experimental data and reported the results happily.

The two have made clear their own positioning. They will not be able to become strategic route designers and chemists full of fantastic ideas for a long time.

Be a company and love a company, no matter which position you are in, do your own job well, it’s fine. Everyone can reap happiness and create life value that fits their own positioning in the ordinary. …