I Just Want to Be a Quiet Top Student

Chapter 537 Invitation from America

“Director Shen, only from the chemical level, c01c-2 succeeded.” Lao Yan is still very excited, after all, there are a lot of innovations in this project.

“To synthesize a new compound, one-third depends on experience and one-third depends on technique. The rest is luck. My luck is better.” Shen Qi asked Lao Yan and Cheng Haonan to do a few more experiments, and then compiled a report.

C01c is a benzothiazinone compound that can theoretically treat diabetes, and it has been verified in rat experiments.

Because of the unsatisfactory effect in the dog experiment, Shen Qi improved the chemical structure of c01c, c01c-2 still uses benzothiazinone as the core, and the side chain is optimized.

After research by Shen Qi, c01c-2 is also a compound for the treatment of type ii diabetes, and it will be verified in animal experiments.

Diabetes is recognized as the most widespread epidemic disease in the world. Today, 200 million patients worldwide are affected by this disease, and the number of patients is expected to double within ten years.

type ii diabetes is a chronic polysaccharide disease accompanied by insulin antibodies, which prevents the pancreas from producing enough insulin to control blood sugar levels.

Many of today’s treatments for type ii diabetes are always unsatisfactory due to their side effects.

Therefore, Shen Qi believes that their research results c01c-2 have very important scientific research value.

At the level of mechanism theory, there is still a puzzle that puzzles Shen Qi.

c01c-2 can be summarized as a non-atp competitive inhibitor of glycogen synthase kinase-3β, among which glycogen synthase kinase-3β is a multifunctional protein kinase and a target related to many diseases, such as diabetes , Alzheimer’s disease, cancer, immune diseases, etc.

Why Shen Qi and the others synthesized c01c and c01c-2, mainly for diabetes, not other diseases?

How to pinpoint the target precisely, what kind of disease does the researcher want to be able to make the corresponding inhibitor?

This requires continuous research to find the real control mechanism.

Ou Ye did not suffer from diabetes, but immune diseases and anemia have long plagued her.

Recently, Ou Ye’s body is not feeling well again. She is weak and lacks energy. Shen Qi was anxious in his eyes.

“No matter what, let’s finish c01c-2 clinically first.” Shen Qi is determined to complete the follow-up testing of c01c-2. Although c01c-2 is set as a type ii diabetes drug, Shen Qi believes that In the process of in-depth research, it is hoped that the true control mechanism of glycogen synthase kinase-3β will be found, and valuable experience and data will be accumulated for the next compound for immune diseases of European leaf.

The title of c01c-2’s paper is “Design, Synthesis and Biological Activity Evaluation of Non-ATP Competitive Inhibitors of Benzothiazinone Glycogen Synthase Kinase-3β”, published in the internationally renowned chemical journal “Journal of the American Chemical Society” .

As mentioned in the article, our research team designed a synthetic route through a new molecular hybridization method, obtained a new type of benzothiazinone compound, and studied its inhibitory activity and kinetic effect on glycogen synthase kinase-3β mode. Studies have shown that this compound has certain reference value for the treatment of type ii diabetes.

The American Chemical Society is very concerned about the research results of Shen Qi’s chemistry group. They said that the paper talked about a new synthesis reaction, which has important academic value.

“Professor Shen, we hope you can come to the United States, and we will organize a high-end academic seminar for you.” The president of the American Chemical Society sincerely invites Shen Qi to come to the United States for academic exchanges.

Shen Qi said on the phone: “I will contact you again after the time is confirmed.”

In addition to the American Chemical Society, the organizations that invited Shen Qi to the United States included the American Mathematical Society, the American Physical Society, the American Academy of Sciences, Princeton University, Harvard University, and California Institute of Technology.

Shen Qi left the United States for five years, during which time he had not been to the United States.

This time Shen Qi changed his mind, he decided to go to America.

Princeton is where Shen Qi used to study and work. He still holds the title of Princeton Honorary Professor of Mathematics, and he refuses the friendly invitation from his alma mater one after another, which is not appropriate.

The American Academy of Sciences awarded Shen Qi the title of foreign academician. Shen Qi accepted the title, and he still had to go to the United States to obtain a certificate when he was free.

In the field of chemistry, Shen Qi has ideas.

System setting, chemistry level 12 is promoted to level 13, Shen Qi must win at least one international chemistry award and 4 million Xueba points.

He won the Nobel Prize for the second time, was awarded foreign academicians from Britain, the United States, France, Russia and other countries, and became a double academician in China. This series of achievements has brought tens of millions of academician points to Shen Qi. He now has no shortage of academician points. Special conditions for completing system settings are missing.

With a new organic reaction, it may be difficult to get the Nobel Prize in Chemistry.

If Shen Qi’s c01c-2 successfully passes several phases of clinical trials and is proven to be the best diabetes drug so far, then he has a chance to get a promise.

Alternatively, if Shen Qi finds the real control mechanism of glycogen synthase kinase-3β inhibitor and can establish a set of mechanism system theory precisely for the target, then he has a higher probability of winning the Nobel Prize in Chemistry or the Prize in Physiology and Medicine.

This is not an overnight effort. After all, chemistry is only level 12 Shen Qi has maxed out almost all the awards that can be awarded in the mathematics and physics circles, and has repeatedly brushed it, and promised to brush twice.

Now, it’s time to brush up on the awards in the chemical industry.

The American Chemical Society has several international chemistry awards. Shen Qi has some thoughts on this, but he can’t be too straightforward. After all, he is a well-known scientist with status and status.

“Leader, I want to go to the United States for academic exchanges, please approve.” Shen Qi reported to the central government, he went to any country, the central government supported it, except the United States.

Leadership: “The spokesperson of the Ministry of Foreign Affairs of our country has repeatedly expressed views at regular press conferences. We are not targeting the United States alone. We expect the United States to return to the right track. We also believe that the United States will become more and more capable under the leadership of the new leadership. Good. But Professor Shen, do you have to go to the United States in person?”

“Leader, there is no way. I have some academic friends in the United States. I have to visit them. They are all 80 or 90 year olds. If you don’t look at them, there will be no chance.” Shen Qi said the truth. Those of his friends in Princeton, one of them hung up not long ago, and two of them went to the hospital bed, dying: “These American academic leaders have given me a lot of academic guidance and help, regardless of political differences. , I should go to the United States to visit my seniors and visit my teachers and friends.”

“Respecting teachers and respecting education is a virtue, and Professor Shen is right to do so.” After careful consideration, the leader agreed to Shen Qi to conduct a friendly academic visit to the United States.

“You’d better not go to the United States alone.” The leader made a suggestion.

“Okay, I originally wanted to take a team to the United States.” Shen Qi said, and immediately began to organize his academic exchange team to the United States. …