I Just Want to Be a Quiet Top Student

Chapter 610 What God can do, chemists can also do

Approaching the end of get off work, Shen Qi saw the experimental report of He Lin’s research team.

Chemistry is an experimental subject, and no matter how great a concept is, it needs to be verified by experiments.

In a seven-membered cyclic transition state reaction, [3, 3] σ migration forms a reaction for the synthesis of macrocyclic compounds. This is a ring-opening method and can be considered a new rearrangement reaction.

The new rearrangement reaction leads to the production of new compounds. Cao Fan believes that the target compound with abnormal structure, in Shen Qi’s view, conforms to his original speculation.

Throughout the history of organic chemistry, new synthetic methods have confirmed certain theories, have also led to the revision or even overthrow of other theories, and at the same time created new compounds that have never appeared.

Some of these new compounds have some practical uses, and some did not know their uses at the time, but they were created by chemists because of their novel structures.

Sea anemone toxin is an unstable compound isolated from the coelenterate sea anemone by chemist Moore in 1971. Its molecular formula is the amazing C129H223N3O54, and its toxicity is more than 10 times that of tetrodotoxin. In 1982, Moore published the three-dimensional structure of the compound. In 1989, Professor Yoshito Kishi of Harvard University announced that the compound was successfully synthesized.

C129H223N3O54 is the largest natural product molecule thought to be synthesized chemically so far. Before the 1990s, chemists synthesized this thing, but at that time they didn’t know what specific environment this thing should be used in.

Entering the 21st century, C129H223N3O54 finally embodies its value. The idea of ​​”what God can do, chemists can do” is widely circulated in the international chemistry community, and Professor Kishi Yoshito has become one of the most outstanding chemists in the world.

It is not clear whether God can save his wife.

So Shen Qi did it himself.

A new drug must be a new compound. Known synthetic methods can be used to synthesize new compounds. Of course, new synthetic methods can also be used.

“This is a seven-membered ring compound, kind.” Shen Qi left the office and went to the chemistry laboratory.

In the laboratory, He Lin is teaching Director Shen’s “Eighteen Pages of Heart Sutra” to Cao Fan.

Not long ago, Shen Qi sent an e-mail to He Lin. The attachment contained some of Shen Qi’s experience on organic synthesis, with a total of 18 pages.

It is based on the “Eighteen pages of the Heart Sutra” that He Lin designed a new experiment and got the results of the experiment today.

“Let me just say, this rearrangement reaction is plausible, like Cope rearrangement but not like it. It turns out that it is a rearrangement reaction newly invented by Director Shen!” Cao Fan suddenly realized that he was very excited, and he was unknowingly. A new reaction was completed: “According to international practice, this rearrangement reaction should be named Shen Qi rearrangement.”

“That is the matter of the International Chemical Organization. It is not our turn to worry.” He Lin said, “The rearrangement reaction invented by Director Shen is just a tool, not the ultimate goal. What he wants most is, one or one A series of representative stable eight- or even nine-membered ring compounds. This new type of macrocyclic compound can support a new set of theories and at the same time produce new drugs that can effectively treat rare diseases that plague patients.”

“Magnificent setting!” After Cao Fan experienced two months of internship, he finally learned the core secret of the LPJK1 project: “So this seven-membered heterocyclic compound is just an intermediate product?”

He Lin nodded and said: “A very meaningful intermediate product. Next, we will do a more in-depth experimental analysis of its stability.”

Six-membered heterocycles widely used in drug synthesis include pyridine, pyrazine, pyrimidine, pyridazine, etc., and their planar structure is hexagonal and their properties are stable.

Also stable are five-element hybrids, including furan, thiophene, pyrrole, thiazole, imidazole, etc., and their planar structure is pentagonal.

The planar structure of the seven-membered heterocyclic compound is heptagonal, and its stability is not as good as that of the five-membered ring and the six-membered ring.

In the ever-changing chemical world, of course there are also triangular three-membered heterocycles, such as ethylene oxide. And square four-membered heterocycles, such as β-propiolactone.

Considering cost, availability and stability, five-membered hybrid and six-membered heterocycles are the most cost-effective.

According to drug naming conventions, we often see a variety of commercial drugs with the words pyridine, pyrazine, pyrimidine, pyridazine, furan, thiophene, pyrrole, thiazole, imidazole, etc. on the market. The main role of these drugs comes from the five-membered hybrid and six-membered heterocycles in their chemical structures.

Why doesn’t Shen Qi follow the rules and focus on five-membered hybrids and six-membered heterocycles?

Because after his calculation and analysis, he believes that a large circle of more than seven yuan is more suitable for the specific project he is doing.

What is the basis for calculation and analysis?

It is mathematics.

As shown in the table above, the reaction of macrocyclic compounds with seven yuan or more is rarely developed, and the supporting theoretical system is not yet perfect.

So there is the rearrangement reaction invented by Shen Qixin.

“He Lin is right. Next, we are going to do stability tests on this seven-element compound.” Shen Qi’s voice sounded behind He Lin and Cao Fan.

“Director Shen!” He Lin and Cao Fan only found Shen Qi behind them quietly.

“I just finished reading the latest experiment report of your group. I did a good job and worked hard. Your group can get off work, let’s go and eat, I invite.” Shen Qi did not hesitate to praise his subordinates, of course, for the subordinates who completed the task. Should give verbal and other encouragement.

The four members of He Lin’s research team happily followed Shen Qi to the restaurant outside. The weather was getting hotter, and the average person ate a few catties of lobster and abalone to moisturize the stomach.

At the dinner, Shen Qi talked about his thoughts on the LPJK1 project: “The first thing we have to do is stability testing to ensure the stability of the rearrangement reaction, seven yuan and subsequent eight yuan, nine yuan or higher compounds www. The stability of the compound is guaranteed, and we will do the work of pharmacokinetic analysis, efficacy and safety. This is the work of animal experiments and clinical trials. The LPJK1 project is divided into several subject groups. The most important group is your receptor antagonist group. The topic of the receptor antagonist group is successfully completed, and LPJK1 is more than half completed. So keep working hard, and I will fight with you.”

“understand!”

“clear!”

Shen Qi raised his glass: “I can’t beat the wine, and I haven’t had a drink in a long time. Today everyone gathered at the table, very happy, I did it, you are free.”

Shen Qi did it as soon as he said, and a glass of white wine was eaten in an instant.

The leader is bored, how can subordinates raise goldfish?

The cohesiveness of the team has been further improved between the staggered ambitions.

Per capita has a bottle of 52-degree liquor. Shen Qi, who is incapable of drinking, gets more sober as he drinks. The four subordinates are blushing and speak truth after drinking.